InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spag1

Summary

InnateDB Protein

IDBP-625264.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spag1

Protein Name

sperm associated antigen 1

Synonyms

tpis;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132233

InnateDB Gene

IDBG-134995 (Spag1)

Protein Structure

UniProt Annotation

Function

May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in cerebellum, tongue, esophagus, forestomach, sperm and testis. {ECO:0000269PubMed:10527845}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0016787	hydrolase activity

Biological Process

GO:0007338	single fertilization
GO:0008152	metabolic process
GO:0070286	axonemal dynein complex assembly

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1349387

InterPro

IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80ZX8