Version 5.4
Mus musculus Gene: Spag1
Summary
InnateDB Gene IDBG-134995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spag1
Gene Name sperm associated antigen 1
Synonyms tpis
Species Mus musculus
Ensembl Gene ENSMUSG00000037617
Encoded Proteins
IDBP-134997
sperm associated antigen 1
IDBP-625264
sperm associated antigen 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104450:
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:36179368-36235610
Strand Forward strand
Band B3.1
Transcripts
ENSMUST00000047348 ENSMUSP00000047335
ENSMUST00000171205 ENSMUSP00000132233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
Biological Process
GO:0007338 single fertilization
GO:0008152 metabolic process
GO:0070286 axonemal dynein complex assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104450
View Gene Order
ENSBTAG00000032544
Not yet available
Cross-References
SwissProt Q80ZX8
TrEMBL
UniProt Splice Variant
Entrez Gene 26942
UniGene Mm.408522
RefSeq NM_012031 XM_006520072 XM_006520073 XM_006520074 XM_006520075 XM_006520076 XM_006520079
OMIM
CCDS CCDS37061
HPRD
IMGT
MGI ID MGI:1349387
MGI Symbol Spag1
EMBL AF181252 AF181253 AK032601 BC046313
GenPept AAF06160 AAF06161 AAH46313 BAC27944
RNA Seq Atlas 26942

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca