InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgd4

Summary

InnateDB Protein

IDBP-625268.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgd4

Protein Name

FYVE, RhoGEF and PH domain containing 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131870

InnateDB Gene

IDBG-137062 (Fgd4)

Protein Structure

UniProt Annotation

Function

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates MAPK8 (By similarity). Plays a role in regulating the actin cytoskeleton and cell shape. Promotes the formation of lamellipodia. {ECO:0000250, ECO:0000269PubMed:10871857, ECO:0000269PubMed:11527409}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in thymus, lung, heart, skeletal muscle, small intestine, liver, kidney, spleen and testis. Expressed in all parts of the brain and in the spinal cord at embryonic, postnatal, and adult stages. Levels of expression are lower in postnatal and adult tissues than in embryonic tissues. {ECO:0000269PubMed:11527409, ECO:0000269PubMed:17564959}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding

Biological Process

GO:0007257	activation of JUN kinase activity
GO:0030032	lamellipodium assembly
GO:0030035	microspike assembly
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0030175	filopodium

Protein Structure and Domains

PDB ID

MGI:2183747

InterPro

IPR000219 Dbl homology (DH) domain
IPR000306 FYVE zinc finger
IPR001849 Pleckstrin homology domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related

PFAM

PF00621
PF01363
PF00169

PRINTS

PIRSF

SMART

SM00325
SM00064
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91ZT5