InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Senp6

Summary

InnateDB Protein

IDBP-625401.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Senp6

Protein Name

SUMO/sentrin specific peptidase 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128918

InnateDB Gene

IDBG-187703 (Senp6)

Protein Structure

UniProt Annotation

Function

Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0008234	cysteine-type peptidase activity
GO:0008270	zinc ion binding
GO:0016929	SUMO-specific protease activity

Biological Process

GO:0006508	proteolysis
GO:0016925	protein sumoylation
GO:0016926	protein desumoylation
GO:0070646	protein modification by small protein removal
GO:0090169	regulation of spindle assembly
GO:0090234	regulation of kinetochore assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1922075

InterPro

IPR003653 Peptidase C48, SUMO/Sentrin/Ubl1

PFAM

PF02902

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6P7W0

PhosphoSite

PhosphoSite-Q6P7W0

TrEMBL

H3BK32

UniProt Splice Variant

Entrez Gene

215351

UniGene

Mm.412479

RefSeq

MGI ID

MGI Symbol

Senp6

OMIM

CCDS

HPRD

IMGT

EMBL

AC142111 AK053904 AK083377 AK129219 BC061480

GenPept

AAH61480 BAC35583 BAC38892 BAC98029