InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbm38

Summary

InnateDB Protein

IDBP-625431.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbm38

Protein Name

RNA binding motif protein 38

Synonyms

Rnpc1; Seb4; Seb4l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133816

InnateDB Gene

IDBG-213353 (Rbm38)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell- specific isoform of FGFR2 (By similarity). Plays a role in myogenic differentiation. {ECO:0000250, ECO:0000269PubMed:19817877}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in cardiac and skeletal muscle tissues. {ECO:0000269PubMed:19817877}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003729	mRNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0008380	RNA splicing
GO:0010830	regulation of myotube differentiation
GO:0030154	cell differentiation
GO:0043484	regulation of RNA splicing
GO:0070935	3'-UTR-mediated mRNA stabilization