Version 5.4
Mus musculus Protein: Slc25a3
Summary
InnateDB Protein IDBP-625504.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc25a3
Protein Name solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
Synonyms 5730556H19Rik; Phc; PTP;
Species Mus musculus
Ensembl Protein ENSMUSP00000132480
InnateDB Gene IDBG-185245 (Slc25a3)
Protein Structure
UniProt Annotation
Function Transport of phosphate groups from the cytosol to mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015293 symporter activity
GO:0032403 protein complex binding
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1353498
InterPro IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain
PFAM PF00153
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VEM8
PhosphoSite PhosphoSite-Q8VEM8
TrEMBL
UniProt Splice Variant
Entrez Gene 18674
UniGene Mm.475470
RefSeq
MGI ID
MGI Symbol Slc25a3
OMIM
CCDS CCDS24121
HPRD
IMGT
EMBL AK077274 AK077723 AK088013 AK150641 AK150729 AK150870 AK151518 AK152006 AK152292 AK152341 AK167197 AK168580 BC018161
GenPept AAH18161 BAC36723 BAC36982 BAC40095 BAE29729 BAE29806 BAE29921 BAE30467 BAE30870 BAE31101 BAE31137 BAE39327 BAE40449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca