InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elf5

Summary

InnateDB Protein

IDBP-625602.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elf5

Protein Name

E74-like factor 5

Synonyms

ESE-2; ESE-5; ESE-5.;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131940

InnateDB Gene

IDBG-193870 (Elf5)

Protein Structure

UniProt Annotation

Function

Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter. {ECO:0000250, ECO:0000269PubMed:16704374, ECO:0000269PubMed:9840936}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00237}.

Disease Associations

Tissue Specificity

Expressed in lung, kidney, stomach, brain, ovaries, tongue, bladder and mammary glands. {ECO:0000269PubMed:9840936}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007398	ectoderm development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060644	mammary gland epithelial cell differentiation