InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Elf5

Summary

InnateDB Gene

IDBG-193870.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elf5

Gene Name

E74-like factor 5

Synonyms

ESE-2; ESE-5; ESE-5.

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027186

Encoded Proteins

IDBP-193872

E74-like factor 5

IDBP-532597

E74-like factor 5

IDBP-625601

E74-like factor 5

IDBP-625602

E74-like factor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135374:
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:103411688-103450989

Strand

Forward strand

Band

Transcripts

ENSMUST00000028609	ENSMUSP00000028609
ENSMUST00000137973
ENSMUST00000126290	ENSMUSP00000118565
ENSMUST00000123793
ENSMUST00000152055
ENSMUST00000164172	ENSMUSP00000126941
ENSMUST00000171693	ENSMUSP00000131940

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007398	ectoderm development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060644	mammary gland epithelial cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000135374

View Gene Order

ENSBTAG00000012460

Not yet available

Cross-References

SwissProt

Q8VDK3

TrEMBL

A2AL22 B1AZI9 Q3V1F7

UniProt Splice Variant

Entrez Gene

13711

UniGene

Mm.20888 Mm.483128

RefSeq

NM_010125 XM_006498705 NM_001145813 XM_006498704

OMIM

CCDS

CCDS16477

HPRD

IMGT

MGI ID

MGI:1335079

MGI Symbol

Elf5

EMBL

AF049702 AK132484 AL773505 AL954374 BC012424 BC021629 CH466519

GenPept

AAC79754 AAH12424 AAH21629 BAE21194 CAM24571 CAM24572 EDL27694 EDL27695

RNA Seq Atlas

13711