Mus musculus Protein: Satb1 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Protein | IDBP-625728.2 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Satb1 | ||||||||||||||||||||||||
Protein Name | special AT-rich sequence binding protein 1 | ||||||||||||||||||||||||
Synonyms | 2610306G12Rik; AW413156; | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000128841 | ||||||||||||||||||||||||
InnateDB Gene | IDBG-190608 (Satb1) | ||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||
Function | Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold- associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin- loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. {ECO:0000250, ECO:0000269PubMed:10716941, ECO:0000269PubMed:11463840, ECO:0000269PubMed:12692553, ECO:0000269PubMed:15814699, ECO:0000269PubMed:17057718, ECO:0000269PubMed:18722016, ECO:0000269PubMed:19103759, ECO:0000269PubMed:19386260, ECO:0000269PubMed:9271405}. | ||||||||||||||||||||||||
Subcellular Localization | Nucleus. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs) (By similarity). {ECO:0000250}. | ||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||
Tissue Specificity | Mainly expressed in thymus, spleen, and lymph nodes with a lower level observed in the brain. {ECO:0000269PubMed:15814699}. | ||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||
PDB ID | MGI:105084 | ||||||||||||||||||||||||
InterPro |
IPR001356
Homeobox domain IPR003350 Homeodomain protein CUT IPR009057 Homeodomain-like IPR010982 Lambda repressor-like, DNA-binding domain |
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PFAM |
PF00046
PF02376 PF13413 |
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PRINTS | |||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||
SMART |
SM00389
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TIGRFAMs | |||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | Q60611 | ||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q60611 | ||||||||||||||||||||||||
TrEMBL | F8WHG2 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 20230 | ||||||||||||||||||||||||
UniGene | Mm.396994 | ||||||||||||||||||||||||
RefSeq | NP_001157103 | ||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||
MGI Symbol | Satb1 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS28876 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AC131975 AC154796 AK088563 AK158518 BC011132 CH466559 CT010371 U05252 | ||||||||||||||||||||||||
GenPept | AAA17372 AAH11132 BAC40427 BAE34542 CAJ18578 EDL23652 | ||||||||||||||||||||||||