InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sin3a

Summary

InnateDB Protein

IDBP-625732.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sin3a

Protein Name

transcriptional regulator, SIN3A (yeast)

Synonyms

AW553200; mKIAA4126; mSin3A; Sin3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126601

InnateDB Gene

IDBG-169269 (Sin3a)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. {ECO:0000269PubMed:10734093, ECO:0000269PubMed:21680841, ECO:0000269PubMed:7889570, ECO:0000269PubMed:8649810}.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highest levels in testis, lung and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 166 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	83 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	166 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032403	protein complex binding
GO:0033558	protein deacetylase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0002218	activation of innate immune response
GO:0002230	positive regulation of defense response to virus by host
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006476	protein deacetylation
GO:0007568	aging
GO:0010243	response to organonitrogen compound
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0031937	positive regulation of chromatin silencing
GO:0034613	cellular protein localization
GO:0042754	negative regulation of circadian rhythm
GO:0043066	negative regulation of apoptotic process
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051595	response to methylglyoxal
GO:0071333	cellular response to glucose stimulus
GO:1900181	negative regulation of protein localization to nucleus
GO:1901675	negative regulation of histone H3-K27 acetylation
GO:2000678	negative regulation of transcription regulatory region DNA binding

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0016580	Sin3 complex
GO:0017053	transcriptional repressor complex