InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sin3a

Summary

InnateDB Gene

IDBG-169269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sin3a

Gene Name

transcriptional regulator, SIN3A (yeast)

Synonyms

AW553200; mKIAA4126; mSin3A; Sin3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042557

Encoded Proteins

IDBP-169273

transcriptional regulator, SIN3A (yeast)

IDBP-625719

transcriptional regulator, SIN3A (yeast)

IDBP-625731

transcriptional regulator, SIN3A (yeast)

IDBP-625732

transcriptional regulator, SIN3A (yeast)

IDBP-625733

transcriptional regulator, SIN3A (yeast)

IDBP-625734

transcriptional regulator, SIN3A (yeast)

IDBP-625736

transcriptional regulator, SIN3A (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169375:
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:57072040-57128366

Strand

Forward strand

Band

Transcripts

ENSMUST00000049169	ENSMUSP00000045044
ENSMUST00000169879	ENSMUSP00000129062
ENSMUST00000167715	ENSMUSP00000130641
ENSMUST00000168678	ENSMUSP00000126601
ENSMUST00000168177	ENSMUSP00000130221
ENSMUST00000163400	ENSMUSP00000126718
ENSMUST00000168502	ENSMUSP00000128956
ENSMUST00000165927
ENSMUST00000167963

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 166 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	83 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	166 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032403	protein complex binding
GO:0033558	protein deacetylase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0002218	activation of innate immune response
GO:0002230	positive regulation of defense response to virus by host
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006476	protein deacetylation
GO:0007568	aging
GO:0010243	response to organonitrogen compound
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0031937	positive regulation of chromatin silencing
GO:0034613	cellular protein localization
GO:0042754	negative regulation of circadian rhythm
GO:0043066	negative regulation of apoptotic process
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051595	response to methylglyoxal
GO:0071333	cellular response to glucose stimulus
GO:1900181	negative regulation of protein localization to nucleus
GO:1901675	negative regulation of histone H3-K27 acetylation
GO:2000678	negative regulation of transcription regulatory region DNA binding

Cellular Component

GO:0000776	kinetochore
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016580	Sin3 complex
GO:0017053	transcriptional repressor complex
GO:0043234	protein complex
GO:0045171	intercellular bridge