InnateDB Protein
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IDBP-625736.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sin3a
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Protein Name
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transcriptional regulator, SIN3A (yeast)
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Synonyms
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AW553200; mKIAA4126; mSin3A; Sin3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000128956
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InnateDB Gene
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IDBG-169269 (Sin3a)
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Protein Structure
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Function |
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. {ECO:0000269PubMed:10734093, ECO:0000269PubMed:21680841, ECO:0000269PubMed:7889570, ECO:0000269PubMed:8649810}.
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Subcellular Localization |
Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highest levels in testis, lung and thymus.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 166 interaction(s) predicted by orthology.
Experimentally validated |
Total |
89
[view]
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Protein-Protein |
83
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
4
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
166 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000976
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transcription regulatory region sequence-specific DNA binding
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GO:0001102
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RNA polymerase II activating transcription factor binding
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GO:0001103
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RNA polymerase II repressing transcription factor binding
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GO:0001106
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RNA polymerase II transcription corepressor activity
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GO:0003677
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DNA binding
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GO:0003682
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chromatin binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003714
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transcription corepressor activity
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GO:0005515
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protein binding
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GO:0008134
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transcription factor binding
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GO:0032403
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protein complex binding
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GO:0033558
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protein deacetylase activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001701
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in utero embryonic development
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GO:0002218
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activation of innate immune response
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GO:0002230
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positive regulation of defense response to virus by host
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GO:0002244
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hematopoietic progenitor cell differentiation
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GO:0006260
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DNA replication
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006476
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protein deacetylation
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GO:0007568
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aging
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GO:0010243
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response to organonitrogen compound
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GO:0010971
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positive regulation of G2/M transition of mitotic cell cycle
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GO:0031937
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positive regulation of chromatin silencing
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GO:0034613
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cellular protein localization
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GO:0042754
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negative regulation of circadian rhythm
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GO:0043066
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negative regulation of apoptotic process
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GO:0043619
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regulation of transcription from RNA polymerase II promoter in response to oxidative stress
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051595
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response to methylglyoxal
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GO:0071333
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cellular response to glucose stimulus
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GO:1900181
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negative regulation of protein localization to nucleus
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GO:1901675
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negative regulation of histone H3-K27 acetylation
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GO:2000678
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negative regulation of transcription regulatory region DNA binding
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Cellular Component |
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PDB ID |
MGI:107157
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InterPro |
IPR003822
Paired amphipathic helix
IPR013194
Histone deacetylase interacting
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PFAM |
PF02671
PF08295
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PRINTS |
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PIRSF |
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SMART |
SM00761
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TIGRFAMs |
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Modification |
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SwissProt |
Q60520
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PhosphoSite |
PhosphoSite-Q60520
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TrEMBL |
E9Q2L1
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UniProt Splice Variant |
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Entrez Gene |
20466
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UniGene |
Mm.15755
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RefSeq |
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MGI ID |
2RMS
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MGI Symbol |
Sin3a
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OMIM |
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CCDS |
CCDS52805
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HPRD |
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IMGT |
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EMBL |
AC132406
AK220292
BC052716
BC053385
L36831
L38620
L38621
U22394
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GenPept |
AAA69772
AAA69773
AAA89119
AAB01610
AAH52716
AAH53385
BAD90217
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