Version 5.4
Mus musculus Protein: Mmel1
Summary
InnateDB Protein IDBP-625737.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mmel1
Protein Name membrane metallo-endopeptidase-like 1
Synonyms Mell1; NEP2; NEPII; Nl1; SEP;
Species Mus musculus
Ensembl Protein ENSMUSP00000131753
InnateDB Gene IDBG-207153 (Mmel1)
Protein Structure
UniProt Annotation
Function Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond. {ECO:0000269PubMed:10542292, ECO:0000269PubMed:11278416}.
Subcellular Localization Membrane {ECO:0000269PubMed:10542292}; Single-pass type II membrane protein {ECO:0000269PubMed:10542292}. Secreted {ECO:0000269PubMed:10542292}. Note=A secreted form produced by proteollytic cleavage also exists.
Disease Associations
Tissue Specificity Highly expressed in testis. Also expressed in ovary. Weakly or not expressed in brain, lung, heart, liver, kidney, adrenal gland and intestine. {ECO:0000269PubMed:10542292}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1351603
InterPro IPR008753 Peptidase M13, N-terminal domain
IPR018497 Peptidase M13, C-terminal domain
PFAM PF05649
PF01431
PRINTS PR00786
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JLI3
PhosphoSite PhosphoSite-Q9JLI3
TrEMBL E9PVK7
UniProt Splice Variant
Entrez Gene 27390
UniGene Mm.116944
RefSeq NP_038811
MGI ID
MGI Symbol Mmel1
OMIM
CCDS CCDS51401
HPRD
IMGT
EMBL AF157105 AF157106 AF176569 AF302075 AF302076 AF302077 AK154366 AL607032
GenPept AAF13152 AAF13153 AAF69247 AAG18446 AAG18447 AAG18448 BAE32538

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca