Version 5.4
Mus musculus Gene: Mmel1
Summary
InnateDB Gene IDBG-207153.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mmel1
Gene Name membrane metallo-endopeptidase-like 1
Synonyms Mell1; NEP2; NEPII; Nl1; SEP
Species Mus musculus
Ensembl Gene ENSMUSG00000058183
Encoded Proteins
IDBP-207155
membrane metallo-endopeptidase-like 1
IDBP-207157
membrane metallo-endopeptidase-like 1
IDBP-270456
membrane metallo-endopeptidase-like 1
IDBP-270458
membrane metallo-endopeptidase-like 1
IDBP-536611
membrane metallo-endopeptidase-like 1
IDBP-625737
membrane metallo-endopeptidase-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142606:
The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:154869585-154895528
Strand Forward strand
Band E2
Transcripts
ENSMUST00000080559 ENSMUSP00000079399
ENSMUST00000079269 ENSMUSP00000078252
ENSMUST00000105635 ENSMUSP00000101260
ENSMUST00000105634 ENSMUSP00000101259
ENSMUST00000131758 ENSMUSP00000121243
ENSMUST00000129623
ENSMUST00000163732 ENSMUSP00000131753
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000142606
View Gene Order
ENSBTAG00000009349
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.116944
RefSeq NM_013783
OMIM
CCDS CCDS51401
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca