InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: B3gnt5

Summary

InnateDB Protein

IDBP-625844.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B3gnt5

Protein Name

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

Synonyms

beta3GnT5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126157

InnateDB Gene

IDBG-143290 (B3gnt5)

Protein Structure

UniProt Annotation

Function

Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in adult spleen, placenta and cerebellar Purkinje cells where it colocalized with HNK-1. Expressed at lower level in brain, lung, thymus and muscle. {ECO:0000269PubMed:11384981}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008378	galactosyltransferase activity
GO:0008457	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
GO:0008917	lipopolysaccharide N-acetylglucosaminyltransferase activity
GO:0047256	lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity