InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ubr4

Summary

InnateDB Protein

IDBP-625857.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubr4

Protein Name

ubiquitin protein ligase E3 component n-recognin 4

Synonyms

1810009A16Rik; A930005E13Rik; D930005K06Rik; Gm1032; Gm1666; mKIAA0462; N28143; p600; RBAF600; Zubr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125800

InnateDB Gene

IDBG-200435 (Ubr4)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. {ECO:0000269PubMed:16055722}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Note=Concentrates at the leading edge of membrane structures involved in actin motility. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed in adult and embryonic stages with highest levels in testis and brain. {ECO:0000269PubMed:16055722}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity