InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Socs2

Summary

InnateDB Protein

IDBP-625908.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Socs2

Protein Name

suppressor of cytokine signaling 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129331

InnateDB Gene

IDBG-187117 (Socs2)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed primarily in the testis, some expression in liver and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005131	growth hormone receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0008269	JAK pathway signal transduction adaptor activity

Biological Process

GO:0001558	regulation of cell growth
GO:0007595	lactation
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0040014	regulation of multicellular organism growth
GO:0040015	negative regulation of multicellular organism growth
GO:0045666	positive regulation of neuron differentiation
GO:0046426	negative regulation of JAK-STAT cascade
GO:0060749	mammary gland alveolus development