Version 5.4
Mus musculus Gene: Socs2
Summary
InnateDB Gene IDBG-187117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Socs2
Gene Name suppressor of cytokine signaling 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020027
Encoded Proteins
IDBP-187121
suppressor of cytokine signaling 2
IDBP-400503
suppressor of cytokine signaling 2
IDBP-531981
suppressor of cytokine signaling 2
IDBP-536487
suppressor of cytokine signaling 2
IDBP-541687
suppressor of cytokine signaling 2
IDBP-538312
suppressor of cytokine signaling 2
IDBP-625908
suppressor of cytokine signaling 2
IDBP-625909
suppressor of cytokine signaling 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:95385362-95417180
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000020215 ENSMUSP00000020215
ENSMUST00000119917 ENSMUSP00000113378
ENSMUST00000139210 ENSMUSP00000121305
ENSMUST00000130784
ENSMUST00000128854
ENSMUST00000155148
ENSMUST00000134918
ENSMUST00000135822 ENSMUSP00000118720
ENSMUST00000150432 ENSMUSP00000117785
ENSMUST00000129942 ENSMUSP00000117576
ENSMUST00000128363
ENSMUST00000145847
ENSMUST00000170690 ENSMUSP00000129331
ENSMUST00000172070 ENSMUSP00000131875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005131 growth hormone receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0008269 JAK pathway signal transduction adaptor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0007595 lactation
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0040014 regulation of multicellular organism growth
GO:0040015 negative regulation of multicellular organism growth
GO:0045666 positive regulation of neuron differentiation
GO:0046426 negative regulation of JAK-STAT cascade
GO:0060749 mammary gland alveolus development
Cellular Component
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_198614
Growth hormone receptor signaling pathway
KEGG
mmu04930
Type II diabetes mellitus pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
Growth hormone signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.411165 Mm.474283
RefSeq NM_001168655 NM_001168656 NM_001168657 NM_007706 XM_006513512 XM_006513519 XM_006513521
OMIM
CCDS CCDS24136
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca