InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map3k12

Summary

InnateDB Protein

IDBP-626042.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k12

Protein Name

mitogen-activated protein kinase kinase kinase 12

Synonyms

DLK; MUK; Zpk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127629

InnateDB Gene

IDBG-188866 (Map3k12)

Protein Structure

UniProt Annotation

Function

May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Expressed in brain, kidney, lung, heart, testis, gastrointestinal tract, stomach, liver and pancreas. Within the nervous system, predominantly expressed in neurons and enriched in synaptic terminals.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0007254	JNK cascade
GO:0016572	histone phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030426	growth cone

Protein Structure and Domains

PDB ID

MGI:1346881

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017419 Mitogen-activated protein kinase kinase kinase, 12/13
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

PIRSF038165

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References