Version 5.4
Mus musculus Protein: Setd1b
Summary
InnateDB Protein IDBP-626068.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Setd1b
Protein Name SET domain containing 1B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000134686
InnateDB Gene IDBG-199221 (Setd1b)
Protein Structure
UniProt Annotation
Function Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus speckle {ECO:0000250}. Chromosome {ECO:0000250}. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SETD1B each bind to a unique set of target genes. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:17355966}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005694 chromosome
GO:0016607 nuclear speck
GO:0048188 Set1C/COMPASS complex
Protein Structure and Domains
PDB ID MGI:2652820
InterPro IPR000504 RNA recognition motif domain
IPR001214 SET domain
IPR003616 Post-SET domain
IPR024657 COMPASS complex Set1 subunit, N-SET domain
PFAM PF00076
PF00856
PF11764
PRINTS
PIRSF
SMART SM00360
SM00317
SM00508
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CFT2
PhosphoSite PhosphoSite-Q8CFT2
TrEMBL
UniProt Splice Variant
Entrez Gene 208043
UniGene Mm.418268
RefSeq
MGI ID
MGI Symbol Setd1b
OMIM
CCDS CCDS59684
HPRD
IMGT
EMBL AC158114 AK122435 BC038367 BC040775 BC041681
GenPept AAH38367 AAH40775 AAH41681 BAC65717

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca