Version 5.4
Mus musculus Protein: Chrm2
Summary
InnateDB Protein IDBP-626191.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chrm2
Protein Name cholinergic receptor, muscarinic 2, cardiac
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000130874
InnateDB Gene IDBG-135963 (Chrm2)
Protein Structure
UniProt Annotation
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0016907 G-protein coupled acetylcholine receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0008016 regulation of heart contraction
GO:0009615 response to virus
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:88397
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000995 Muscarinic acetylcholine receptor family
IPR001065 Muscarinic acetylcholine receptor M2
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR00243
PR00539
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ERZ4
PhosphoSite PhosphoSite-Q9ERZ4
TrEMBL
UniProt Splice Variant
Entrez Gene 243764
UniGene Mm.448632
RefSeq NP_987076
MGI ID
MGI Symbol Chrm2
OMIM
CCDS CCDS20004
HPRD
IMGT
EMBL AC113246 AC159505 AF264049
GenPept AAG14343

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca