InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chrm2

Summary

InnateDB Gene

IDBG-135963.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrm2

Gene Name

cholinergic receptor, muscarinic 2, cardiac

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000045613

Encoded Proteins

IDBP-626191

cholinergic receptor, muscarinic 2, cardiac

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181072:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:36388084-36528414

Strand

Forward strand

Band

Transcripts

ENSMUST00000172278	ENSMUSP00000130874
ENSMUST00000169004

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016907	G-protein coupled acetylcholine receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0008016	regulation of heart contraction
GO:0009615	response to virus

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane