InnateDB Protein
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IDBP-626212.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ikbkg
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Protein Name
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inhibitor of kappaB kinase gamma
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Synonyms
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1110037D23Rik; AI848108; AI851264; AW124339; IKK[g]; NEMO;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000126770
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InnateDB Gene
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IDBG-156458 (Ikbkg)
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Protein Structure
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Function |
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. {ECO:0000269PubMed:9927690}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 356 interaction(s) predicted by orthology.
Experimentally validated |
Total |
95
[view]
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Protein-Protein |
95
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
356 [view]
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Molecular Function |
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Biological Process |
GO:0001782
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B cell homeostasis
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GO:0006351
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transcription, DNA-templated
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GO:0006974
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cellular response to DNA damage stimulus
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GO:0007250
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activation of NF-kappaB-inducing kinase activity
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051092
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positive regulation of NF-kappaB transcription factor activity
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Cellular Component |
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PDB ID |
MGI:1338074
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InterPro |
IPR021063
NF-kappa-B essential modulator NEMO, N-terminal
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PFAM |
PF11577
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O88522
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PhosphoSite |
PhosphoSite-O88522
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TrEMBL |
A3KG44
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UniProt Splice Variant |
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Entrez Gene |
16151
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UniGene |
Mm.12967
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RefSeq |
NP_001154895
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MGI ID |
4OWF
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MGI Symbol |
Ikbkg
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OMIM |
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CCDS |
CCDS41023
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HPRD |
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IMGT |
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EMBL |
AF069542
AF326207
AF513109
AK154095
AL669976
AL807376
CH466650
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GenPept |
AAC40153
AAK69186
AAP47160
BAE32372
CAM45971
EDL29810
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