InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nlrx1

Summary

InnateDB Protein

IDBP-626228.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nlrx1

Protein Name

NLR family member X1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126555

InnateDB Gene

IDBG-156238 (Nlrx1)

Protein Structure

UniProt Annotation

Function

Participates in antiviral signaling. {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0016032	viral process
GO:0032688	negative regulation of interferon-beta production
GO:0032715	negative regulation of interleukin-6 production
GO:0039536	negative regulation of RIG-I signaling pathway
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045824	negative regulation of innate immune response
GO:0050728	negative regulation of inflammatory response

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane

Protein Structure and Domains

PDB ID

MGI:2429611

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR007111 NACHT nucleoside triphosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3TL44

PhosphoSite