InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nlrx1

Summary

InnateDB Gene

IDBG-156238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nlrx1

Gene Name

NLR family member X1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032109

Encoded Proteins

IDBP-156240

NLR family member X1

IDBP-626225

NLR family member X1

IDBP-626228

NLR family member X1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21703540

Nlrx1 deletion leads to constitutive interaction of Mavs and Ddx58, resulting in increased inflammation. Nlrx1 knockout mice showed increased expression of antiviral signalling molecules such as Ifnb, Stat2, Oas1 and Il6 after influenza infection. In addition to attenuating the antiviral response, Nlrx1 directly associates with Traf6 and inhibits NFkB pathway in LPS-activated macrophages.

PMID 21703539

Nlrx1 negatively regulates TLR-mediated NFkB activation by directly interacting with Traf6 or IKK kinase. Nlrx1 knockdown in mice enhances their susceptibility to LPS-induced septic shock and increases plasma Il6 levels.

PMID 22749352

Nlrx1 attenuates type I IFN production and promotes autophagy during viral infection. (Demonstrated in human)

PMID 24366868

Nlrx1 attenuates macrophage/microglial inflammatory activities and protects against experimental autoimmune encephalomyelitis caused by autoreactive T cells.

InnateDB Annotation from Orthologs

Summary

PMID 18311173

[Homo sapiens] NLRX1 is an amplifier of ROS generation and an inhibitor of antiviral mitochondrial signalling with markedly increased IFN-β responses in cells with down-regulated NLRX1 expression.

PMID 18200010

[Homo sapiens] NLRX1 depletion via siRNA promotes virus-induced type 1 interferon production and decreases viral replication.

PMID 18280719

[Homo sapiens] NLRX1 is an important regulator of the type I interferon (IFN) response, and prevents MAVS from signalling the activation of a type I IFN response by the RNA helicases

PMID 21703540

[Homo sapiens] NLRX1 deletion leads to constitutive interaction of MAVS and DDX58, resulting in increased inflammation. In addition to attenuating the antiviral response, NLRX1 directly associates with TRAF6 and inhibits NFkB pathway in LPS-activated macrophages.

PMID 21703539

[Homo sapiens] NLRX1 negatively regulates TLR-mediated NFkB activation by directly interacting with TRAF6 or IKK kinase. Nlrx1 knockdown in mice enhances their susceptibility to LPS-induced septic shock and increases plasma IL6 levels.

PMID 22749352

[Homo sapiens] NLRX1 attenuates type I IFN production and promotes autophagy during viral infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160703:
This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:44252713-44268599

Strand

Reverse strand

Band

A5.2

Transcripts

ENSMUST00000034621	ENSMUSP00000034621
ENSMUST00000168499	ENSMUSP00000127531
ENSMUST00000169651	ENSMUSP00000126555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0016032	viral process
GO:0032688	negative regulation of interferon-beta production
GO:0032715	negative regulation of interleukin-6 production
GO:0039536	negative regulation of RIG-I signaling pathway
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045824	negative regulation of innate immune response
GO:0050728	negative regulation of inflammatory response

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000160703

View Gene Order

ENSBTAG00000040569

Not yet available

Pathways

NETPATH

REACTOME

REACT_239142

Innate Immune System pathway

REACT_198532

Negative regulators of RIG-I/MDA5 signaling pathway

REACT_230745

Immune System pathway

REACT_219118

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway

KEGG

mmu04622

RIG-I-like receptor signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25271

Negative regulators of RIG-I/MDA5 signaling pathway

REACT_25359

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04622

RIG-I-like receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.3957 Mm.466338

RefSeq

NM_001163742 NM_001163743 NM_178420

OMIM

CCDS

CCDS23100

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas