InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Guk1

Summary

InnateDB Protein

IDBP-626260.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Guk1

Protein Name

guanylate kinase 1

Synonyms

AA409738; AL033299; AL033300; AV026611; Gmk; Guk-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130214

InnateDB Gene

IDBG-178338 (Guk1)

Protein Structure

UniProt Annotation

Function

Essential for recycling GMP and indirectly, cGMP.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004385	guanylate kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006163	purine nucleotide metabolic process
GO:0006185	dGDP biosynthetic process
GO:0019673	GDP-mannose metabolic process
GO:0034436	glycoprotein transport
GO:0046034	ATP metabolic process
GO:0046037	GMP metabolic process
GO:0046054	dGMP metabolic process
GO:0046060	dATP metabolic process
GO:0046711	GDP biosynthetic process
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

MGI:95871

InterPro

IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR017665 Guanylate kinase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00625

PRINTS

PIRSF

SMART

SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64520