InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Guk1

Summary

InnateDB Gene

IDBG-178338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Guk1

Gene Name

guanylate kinase 1

Synonyms

AA409738; AL033299; AL033300; AV026611; Gmk; Guk-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020444

Encoded Proteins

IDBP-626255

guanylate kinase 1

IDBP-626260

guanylate kinase 1

IDBP-626263

guanylate kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143774:
The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:59183875-59192212

Strand

Reverse strand

Band

B1.3

Transcripts

ENSMUST00000151211
ENSMUST00000154386
ENSMUST00000130815
ENSMUST00000170202	ENSMUSP00000127566
ENSMUST00000170895	ENSMUSP00000130214
ENSMUST00000172714	ENSMUSP00000134236

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004385	guanylate kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016301	kinase activity

Biological Process

GO:0006163	purine nucleotide metabolic process
GO:0006185	dGDP biosynthetic process
GO:0019673	GDP-mannose metabolic process
GO:0034436	glycoprotein transport
GO:0046034	ATP metabolic process
GO:0046037	GMP metabolic process
GO:0046054	dGMP metabolic process
GO:0046060	dATP metabolic process
GO:0046711	GDP biosynthetic process
GO:0046939	nucleotide phosphorylation