InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pglyrp2

Summary

InnateDB Protein

IDBP-626264.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pglyrp2

Protein Name

peptidoglycan recognition protein 2

Synonyms

C730002N09Rik; Pglyrpl; PGRP-L; tagL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129964

InnateDB Gene

IDBG-251732 (Pglyrp2)

Protein Structure

UniProt Annotation

Function

May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.

Subcellular Localization

Secreted. Membrane.

Disease Associations

Tissue Specificity

Strongly expressed in liver and fetal liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
GO:0016019	peptidoglycan receptor activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0009253	peptidoglycan catabolic process
GO:0016045	detection of bacterium
GO:0032689	negative regulation of interferon-gamma production
GO:0032827	negative regulation of natural killer cell differentiation involved in immune response
GO:0044117	growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium