InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KNTC1

Summary

InnateDB Protein

IDBP-62632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KNTC1

Protein Name

kinetochore associated 1

Synonyms

ROD;

Species

Homo sapiens

Ensembl Protein

ENSP00000328236

InnateDB Gene

IDBG-62630 (KNTC1)

Protein Structure

UniProt Annotation

Function

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. {ECO:0000269PubMed:11146660, ECO:0000269PubMed:11590237, ECO:0000269PubMed:15824131}.

Subcellular Localization

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles.

Disease Associations

Tissue Specificity

High expression in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0007067	mitotic nuclear division
GO:0007093	mitotic cell cycle checkpoint
GO:0007096	regulation of exit from mitosis

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005828	kinetochore microtubule
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR003822 Paired amphipathic helix
IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
IPR017986 WD40-repeat-containing domain
IPR019527 RZZ complex, subunit KNTC1/ROD, C-terminal

PFAM

PF02671
PF10493

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50748

PhosphoSite