Version 5.4
| Mus musculus Protein: Ntsr1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-626343.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Ntsr1 | ||||||||
| Protein Name | neurotensin receptor 1 | ||||||||
| Synonyms | NT-1R; NTR-1; NTR1; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000127548 | ||||||||
| InnateDB Gene | IDBG-213841 (Ntsr1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane raft {ECO:0000250}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:97386 | ||||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR003984 Neurotensin receptor IPR003985 Neurotensin type 1 receptor IPR017452 GPCR, rhodopsin-like, 7TM IPR019426 7TM GPCR, serpentine receptor class v (Srv) |
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| PFAM |
PF00001
PF10323 |
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| PRINTS |
PR00237
PR01479 PR01480 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | O88319 | ||||||||
| PhosphoSite | PhosphoSite-O88319 | ||||||||
| TrEMBL | Q9QZQ2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 18216 | ||||||||
| UniGene | Mm.301712 | ||||||||
| RefSeq | |||||||||
| MGI ID | |||||||||
| MGI Symbol | Ntsr1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS17177 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB017027 AF172326 BC138630 BC138633 CH466626 | ||||||||
| GenPept | AAD51806 AAI38631 AAI38634 BAA33013 EDL07336 | ||||||||