InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptp4a2

Summary

InnateDB Protein

IDBP-626375.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptp4a2

Protein Name

protein tyrosine phosphatase 4a2

Synonyms

Prl-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125901

InnateDB Gene

IDBG-191662 (Ptp4a2)

Protein Structure

UniProt Annotation

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10747914}. Early endosome {ECO:0000269PubMed:10747914}. Cytoplasm {ECO:0000269PubMed:10747914}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle, and at lower levels in liver, lung, heart, kidney, brain, testis and spleen. {ECO:0000269PubMed:9514946}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005769	early endosome
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1277117

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt