Mus musculus Gene: Ptp4a2
Summary
InnateDB Gene IDBG-191662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptp4a2
Gene Name protein tyrosine phosphatase 4a2
Synonyms Prl-2
Species Mus musculus
Ensembl Gene ENSMUSG00000028788
Encoded Proteins
protein tyrosine phosphatase 4a2
protein tyrosine phosphatase 4a2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184007:
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:129811219-129850003
Strand Forward strand
Band D2.2
Transcripts
ENSMUST00000030578 ENSMUSP00000030578
ENSMUST00000132386
ENSMUST00000132411
ENSMUST00000127558
ENSMUST00000133662
ENSMUST00000141754
ENSMUST00000165853 ENSMUSP00000125901
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Signaling events mediated by PRL
Cross-References
SwissProt O70274
TrEMBL Q3UXF9
UniProt Splice Variant
Entrez Gene 19244
UniGene Mm.193688 Mm.394150 Mm.403155 Mm.406457 Mm.439824 Mm.446241 Mm.470778
RefSeq NM_008974 NM_001164745
OMIM
CCDS CCDS18704
HPRD
IMGT
MGI ID MGI:1277117
MGI Symbol Ptp4a2
EMBL AF035644 AK033092 AK045093 AK135662 AK155895 BC086794 BC087551
GenPept AAC15874 AAH86794 AAH87551 BAC28149 BAC32217 BAE22604 BAE33489
RNA Seq Atlas 19244