Version 5.4
| Mus musculus Protein: Med12l | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-626516.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Med12l | ||||||||
| Protein Name | mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)-like | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000127038 | ||||||||
| InnateDB Gene | IDBG-146676 (Med12l) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Nucleus {ECO:0000305}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2139916 | ||||||||
| InterPro |
IPR019035
Mediator complex, subunit Med12 IPR021989 Mediator complex, subunit Med12, catenin-binding IPR021990 Mediator complex, subunit Med12, LCEWAV-domain |
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| PFAM |
PF09497
PF12144 PF12145 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8BQM9 | ||||||||
| PhosphoSite | PhosphoSite-Q8BQM9 | ||||||||
| TrEMBL | Q6ZPK9 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 329650 | ||||||||
| UniGene | Mm.240059 | ||||||||
| RefSeq | NP_808523 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Med12l | ||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC115919 AC122038 AK042296 AK047743 AK129412 AK129475 | ||||||||
| GenPept | BAC31219 BAC33144 BAC98222 BAC98285 | ||||||||