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InnateDB Protein
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IDBP-626600.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cnot2
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Protein Name
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CCR4-NOT transcription complex, subunit 2
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Synonyms
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2600016M12Rik; 2810470K03Rik; AA537049; AA959607; AW557563; C79650;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000132152
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InnateDB Gene
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IDBG-191316 (Cnot2)
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Protein Structure
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| Function |
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. {ECO:0000269PubMed:22367759}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
26 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0001226
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RNA polymerase II transcription corepressor binding
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GO:0004535
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poly(A)-specific ribonuclease activity
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| Biological Process |
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GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001829
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trophectodermal cell differentiation
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006417
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regulation of translation
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GO:0010606
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positive regulation of cytoplasmic mRNA processing body assembly
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GO:0031047
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gene silencing by RNA
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GO:0033147
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negative regulation of intracellular estrogen receptor signaling pathway
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GO:0090503
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RNA phosphodiester bond hydrolysis, exonucleolytic
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GO:2000036
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regulation of stem cell maintenance
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| Cellular Component |
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| PDB ID |
MGI:1919318
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| InterPro |
IPR007282
NOT2/NOT3/NOT5
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| PFAM |
PF04153
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q8C5L3
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| PhosphoSite |
PhosphoSite-Q8C5L3
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
72068
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| UniGene |
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| RefSeq |
NP_001032936
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| MGI ID |
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| MGI Symbol |
Cnot2
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| OMIM |
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| CCDS |
CCDS36064
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| HPRD |
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| IMGT |
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| EMBL |
AK011231
AK078121
AK149767
BC043133
BC063105
BC065171
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| GenPept |
AAH43133
AAH63105
AAH65171
BAB27481
BAC37134
BAE29072
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Version 5.4