Version 5.4
Mus musculus Protein: Crb3
Summary
InnateDB Protein IDBP-626749.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crb3
Protein Name crumbs homolog 3 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000132502
InnateDB Gene IDBG-193569 (Crb3)
Protein Structure
UniProt Annotation
Function Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions (By similarity). {ECO:0000250}.
Subcellular Localization Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0017124 SH3 domain binding
Biological Process
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045216 cell-cell junction organization
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0043234 protein complex
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID MGI:2670904
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8QZT4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 224912
UniGene Mm.486719
RefSeq XP_006524229
MGI ID
MGI Symbol Crb3
OMIM
CCDS CCDS28924
HPRD
IMGT
EMBL AK077528 AK167279 BC024462 CK030526
GenPept AAH24462 BAC36847 BAE39389

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca