Version 5.4
Mus musculus Gene: Crb3
Summary
InnateDB Gene IDBG-193569.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crb3
Gene Name crumbs homolog 3 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000044279
Encoded Proteins
IDBP-193571
crumbs homolog 3 (Drosophila)
IDBP-193573
crumbs homolog 3 (Drosophila)
IDBP-626748
crumbs homolog 3 (Drosophila)
IDBP-626749
crumbs homolog 3 (Drosophila)
IDBP-626750
crumbs homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130545:
This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:57059105-57065918
Strand Forward strand
Band D
Transcripts
ENSMUST00000071826 ENSMUSP00000071729
ENSMUST00000097299 ENSMUSP00000094902
ENSMUST00000169543 ENSMUSP00000125760
ENSMUST00000163763 ENSMUSP00000132502
ENSMUST00000163628 ENSMUSP00000126402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0017124 SH3 domain binding
GO:0019904 protein domain specific binding
Biological Process
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045216 cell-cell junction organization
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030054 cell junction
GO:0043234 protein complex
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000130545
View Gene Order
Pathways
NETPATH
REACTOME
REACT_248094
Cell-cell junction organization pathway
REACT_241978
Cell junction organization pathway
REACT_236746
Tight junction interactions pathway
REACT_223082
Cell-Cell communication pathway
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.391027 Mm.486197 Mm.486719
RefSeq NM_177638 XM_006524164 XM_006524167
OMIM
CCDS CCDS28924
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca