InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Enpp2

Summary

InnateDB Protein

IDBP-626807.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Enpp2

Protein Name

ectonucleotide pyrophosphatase/phosphodiesterase 2

Synonyms

ATX; lysoPLD; Npps2; PD-Ialpha; Pdnp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128941

InnateDB Gene

IDBG-140731 (Enpp2)

Protein Structure

UniProt Annotation

Function

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. {ECO:0000269PubMed:17208043, ECO:0000269PubMed:21240269}.

Subcellular Localization

Secreted {ECO:0000269PubMed:17208043, ECO:0000269PubMed:21240269}. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells (By similarity). {ECO:0000250}.

Disease Associations

Note=May contribute to obesity.

Tissue Specificity

Expressed in brain and adipose tissue. {ECO:0000269PubMed:18175805}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004528	phosphodiesterase I activity
GO:0004551	nucleotide diphosphatase activity
GO:0004622	lysophospholipase activity
GO:0005044	scavenger receptor activity
GO:0005509	calcium ion binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0030247	polysaccharide binding
GO:0046872	metal ion binding
GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0008152	metabolic process
GO:0030334	regulation of cell migration
GO:0034638	phosphatidylcholine catabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005615	extracellular space
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

MGI:1321390

InterPro

IPR001212 Somatomedin B domain
IPR001604 DNA/RNA non-specific endonuclease
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR017850 Alkaline-phosphatase-like, core domain
IPR020436 Somatomedin B, chordata
IPR020821 Extracellular Endonuclease, subunit A

PFAM

PF01033
PF01223
PF01663

PRINTS

PR00022

PIRSF

SMART

SM00201
SM00892
SM00477

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt