Version 5.4
Mus musculus Gene: Enpp2
Summary
InnateDB Gene IDBG-140731.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Enpp2
Gene Name ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms ATX; lysoPLD; Npps2; PD-Ialpha; Pdnp2
Species Mus musculus
Ensembl Gene ENSMUSG00000022425
Encoded Proteins
IDBP-140733
ectonucleotide pyrophosphatase/phosphodiesterase 2
IDBP-626805
ectonucleotide pyrophosphatase/phosphodiesterase 2
IDBP-626806
ectonucleotide pyrophosphatase/phosphodiesterase 2
IDBP-626807
ectonucleotide pyrophosphatase/phosphodiesterase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136960:
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5\' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:54838898-54920146
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000041591 ENSMUSP00000036180
ENSMUST00000173516 ENSMUSP00000133877
ENSMUST00000167541 ENSMUSP00000132640
ENSMUST00000171545 ENSMUSP00000128941
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003824 catalytic activity
GO:0004528 phosphodiesterase I activity
GO:0004551 nucleotide diphosphatase activity
GO:0004622 lysophospholipase activity
GO:0005044 scavenger receptor activity
GO:0005509 calcium ion binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0030247 polysaccharide binding
GO:0046872 metal ion binding
GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
GO:0030334 regulation of cell migration
GO:0034638 phosphatidylcholine catabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136960
View Gene Order
ENSBTAG00000013165
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00565
Ether lipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00565
Ether lipid metabolism pathway
INOH
INOH website
Nicotinate Nicotinamide metabolism pathway
PID NCI
Cross-References
SwissProt Q9R1E6
TrEMBL G3UXY9 Q9R1D5
UniProt Splice Variant
Entrez Gene 18606
UniGene
RefSeq NM_001136077 NM_001285994 NM_001285995 NM_015744 XM_006520593 XM_006520594 XM_006520595 XM_006520596
OMIM
CCDS CCDS27472 CCDS49607 CCDS70628 CCDS70629
HPRD
IMGT
MGI ID MGI:1321390
MGI Symbol Enpp2
EMBL AC123644 AF123542 AF128879 AK161144 BC003264 BC058759 CH466545 EU131009 EU131010 EU677474 EU677475
GenPept AAD46480 AAD50640 AAH03264 AAH58759 ABW38314 ABW38315 ACD12865 ACD12866 BAE36214 EDL29265
RNA Seq Atlas 18606

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca