InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agpat6

Summary

InnateDB Protein

IDBP-626956.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agpat6

Protein Name

1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)

Synonyms

AU041707; AW545732; GPAT4; Tsarg7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127325

InnateDB Gene

IDBG-141928 (Agpat6)

Protein Structure

UniProt Annotation

Function

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004366	glycerol-3-phosphate O-acyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0002071	glandular epithelial cell maturation
GO:0006631	fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0006641	triglyceride metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0007595	lactation
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0016024	CDP-diacylglycerol biosynthetic process
GO:0019432	triglyceride biosynthetic process
GO:0030879	mammary gland development
GO:0040014	regulation of multicellular organism growth
GO:0046339	diacylglycerol metabolic process