InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pnpla2

Summary

InnateDB Protein

IDBP-626961.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pnpla2

Protein Name

patatin-like phospholipase domain containing 2

Synonyms

0610039C21Rik; 1110001C14Rik; Atgl; TTS-2.2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127149

InnateDB Gene

IDBG-212233 (Pnpla2)

Protein Structure

UniProt Annotation

Function

Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. {ECO:0000269PubMed:15337759, ECO:0000269PubMed:15550674, ECO:0000269PubMed:16150821, ECO:0000269PubMed:16675698, ECO:0000269PubMed:16679289, ECO:0000269PubMed:17074755}.

Subcellular Localization

Lipid droplet. Cell membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Expressed at high levels in white and brown adipose tissue, and to a lesser degree in testis and cardiac muscle. Barely detected in liver, spleen, thymus, kidney, skeletal muscle, and brain. Among the white adipose depots, gonadal fat showed the highest level of expression compared with inguinal and renal white adipose tissues. {ECO:0000269PubMed:15337759, ECO:0000269PubMed:15550674, ECO:0000269PubMed:16150821, ECO:0000269PubMed:16705060}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004806	triglyceride lipase activity
GO:0005515	protein binding

Biological Process

GO:0006629	lipid metabolic process
GO:0008152	metabolic process
GO:0010891	negative regulation of sequestering of triglyceride
GO:0010898	positive regulation of triglyceride catabolic process
GO:0019433	triglyceride catabolic process
GO:0019915	lipid storage
GO:0034389	lipid particle organization

Cellular Component

GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle