InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhx30

Summary

InnateDB Protein

IDBP-627088.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhx30

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 30

Synonyms

2810477H02Rik; C130058C04Rik; Ddx30; HELG; Ret-CoR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129174

InnateDB Gene

IDBG-201735 (Dhx30)

Protein Structure

UniProt Annotation

Function

Associates with mitochondrial DNA. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. {ECO:0000250}.

Subcellular Localization

Isoform 3: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}.Isoform 2: Cytoplasm {ECO:0000250}.Isoform 1: Cytoplasm {ECO:0000250}.Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}. Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003682	chromatin binding
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0008150	biological_process

Cellular Component

GO:0042645

mitochondrial nucleoid

Protein Structure and Domains

PDB ID

MGI:1920081

InterPro

IPR001650 Helicase, C-terminal
IPR007502 Helicase-associated domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99PU8