InnateDB Protein
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IDBP-627095.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mtbp
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Protein Name
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Mdm2, transformed 3T3 cell double minute p53 binding protein
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Synonyms
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AI429604; MDM2BP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000129396
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InnateDB Gene
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IDBG-141711 (Mtbp)
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Protein Structure
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Function |
May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. {ECO:0000269PubMed:10906133, ECO:0000269PubMed:15632057}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expressed in small intestine and spleen at low levels, in the ovary at intermediate levels and in the testis and thymus at high levels. {ECO:0000269PubMed:10906133}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2146005
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BJS8
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PhosphoSite |
PhosphoSite-Q8BJS8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
105837
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UniGene |
Mm.484012
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RefSeq |
NP_001161722
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MGI ID |
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MGI Symbol |
Mtbp
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OMIM |
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CCDS |
CCDS49609
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HPRD |
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IMGT |
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EMBL |
AJ278508
AK080036
AK088549
AK088652
AK133855
BC005500
BC052197
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GenPept |
AAH05500
AAH52197
BAC37810
BAC40418
BAC40479
BAE21889
CAC07970
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