Version 5.4
Mus musculus Protein: Mtbp
Summary
InnateDB Protein IDBP-627097.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mtbp
Protein Name Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms AI429604; MDM2BP;
Species Mus musculus
Ensembl Protein ENSMUSP00000128615
InnateDB Gene IDBG-141711 (Mtbp)
Protein Structure
UniProt Annotation
Function May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. {ECO:0000269PubMed:10906133, ECO:0000269PubMed:15632057}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in small intestine and spleen at low levels, in the ovary at intermediate levels and in the testis and thymus at high levels. {ECO:0000269PubMed:10906133}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007050 cell cycle arrest
GO:0007089 traversing start control point of mitotic cell cycle
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:2146005
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BJS8
PhosphoSite PhosphoSite-Q8BJS8
TrEMBL
UniProt Splice Variant
Entrez Gene 105837
UniGene Mm.484012
RefSeq
MGI ID
MGI Symbol Mtbp
OMIM
CCDS
HPRD
IMGT
EMBL AJ278508 AK080036 AK088549 AK088652 AK133855 BC005500 BC052197
GenPept AAH05500 AAH52197 BAC37810 BAC40418 BAC40479 BAE21889 CAC07970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca