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InnateDB Protein
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IDBP-627098.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Senp8
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Protein Name
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SUMO/sentrin specific peptidase 8
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Synonyms
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9130010J17Rik; AU020827; Den1; Nedp1; Prsc2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000129441
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InnateDB Gene
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IDBG-173389 (Senp8)
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Protein Structure
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| Function |
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. {ECO:0000269PubMed:12759362}.
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
1
[view]
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| Protein-Protein |
1
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
14 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0008234
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cysteine-type peptidase activity
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GO:0019784
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NEDD8-specific protease activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1918849
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| InterPro |
IPR003653
Peptidase C48, SUMO/Sentrin/Ubl1
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| PFAM |
PF02902
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q9D2Z4
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
71599
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| UniGene |
Mm.469182
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| RefSeq |
NP_001165542
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| MGI ID |
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| MGI Symbol |
Senp8
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| OMIM |
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| CCDS |
CCDS52819
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| HPRD |
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| IMGT |
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| EMBL |
AK018606
AK049120
BC037443
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| GenPept |
AAH37443
BAB31304
BAC33554
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Version 5.4