InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alox5

Summary

InnateDB Protein

IDBP-627126.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alox5

Protein Name

arachidonate 5-lipoxygenase

Synonyms

5-LO; 5-LOX; 5LO; 5LX; AI850497; F730011J02;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130780

InnateDB Gene

IDBG-180618 (Alox5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding

Biological Process

GO:0002540	leukotriene production involved in inflammatory response
GO:0006691	leukotriene metabolic process
GO:0006954	inflammatory response
GO:0019370	leukotriene biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:87999

InterPro

IPR001024 PLAT/LH2 domain
IPR001885 Lipoxygenase, mammalian
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013819 Lipoxygenase, C-terminal

PFAM

PF01477
PF00305

PRINTS

PR00467
PR00087

PIRSF

SMART

SM00308

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9QA93

UniProt Splice Variant

Entrez Gene

11689

UniGene

Mm.482570

RefSeq

MGI ID

MGI Symbol

Alox5

OMIM

CCDS

HPRD

IMGT

EMBL

AC123548

GenPept