Version 5.4
Mus musculus Protein: Klrb1c
Summary
InnateDB Protein IDBP-627151.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klrb1c
Protein Name killer cell lectin-like receptor subfamily B member 1C
Synonyms AI462337; CD161; ly-55c; Ly-59; Ly55c; Ly59; Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1; NKRP140; Nkrp1c;
Species Mus musculus
Ensembl Protein ENSMUSP00000134504
InnateDB Gene IDBG-191576 (Klrb1c)
Protein Structure
UniProt Annotation
Function Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production. {ECO:0000269PubMed:12813047, ECO:0000269PubMed:15814704}.
Subcellular Localization Membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity Expressed in natural killer cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0030101 natural killer cell activation
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:107538
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P27814
PhosphoSite PhosphoSite-
TrEMBL Q7TQ26
UniProt Splice Variant
Entrez Gene 17059
UniGene Mm.480764
RefSeq NP_001153376
MGI ID
MGI Symbol Klrb1c
OMIM
CCDS CCDS51919
HPRD
IMGT
EMBL AC102693 AF354263 AK079743 AY007206 AY316227 BC061168 M77678
GenPept AAA39824 AAG02283 AAH61168 AAK39103 AAP82935 BAC37739

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca