InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mid1

Summary

InnateDB Protein

IDBP-627191.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mid1

Protein Name

midline 1

Synonyms

61B3-R; DXHXS1141; Fxy; Trim18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126746

InnateDB Gene

IDBG-186021 (Mid1)

Protein Structure

UniProt Annotation

Function

Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Microtubule-associated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in fetus and adult. At E9-E10.5, highest expression found in frontonasal processes, branchial arches and CNS. From E12.5 to E16.5, high levels found in rostral part of CNS. At E14.5, begins to be highly expressed in kidney and lung. At E16.5, highly expressed in the mucosa of the hindgut and cutaneous region of the stomach. {ECO:0000269PubMed:9722948}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007026	negative regulation of microtubule depolymerization
GO:0008152	metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1100537

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003649 B-box, C-terminal
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR003961 Fibronectin, type III
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM