InnateDB Protein
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IDBP-627273.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ube2j2
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Protein Name
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ubiquitin-conjugating enzyme E2, J2 homolog (yeast)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000127712
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InnateDB Gene
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IDBG-208149 (Ube2j2)
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Protein Structure
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Function |
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).In case of infection by the murid herpesvirus 4, its association with the viral E3 ligase K3 mediates ubiquitination of host surface class I (MHC-I) H-2D(b)/H2-D1 and H-2K(b)/H2-K1 molecules before they exit the endoplasmic reticulum, leading to their degradation by the ERAD system, thus blocking the immune detection of virus-infected cells. The complex formed with the murid herpesvirus 4 protein K3 mediates ubiquitination of lysine, as well as serine and threonine residues present in the cytoplasmic tail of surface class I molecules and promotes ubiquitination of hydroxylated serine or threonine residues via ester bonds instead of the classical isopeptide linkage.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:11278356, ECO:0000269PubMed:12082160}; Single-pass type IV membrane protein {ECO:0000269PubMed:11278356, ECO:0000269PubMed:12082160}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2153608
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6P073
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PhosphoSite |
PhosphoSite-
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TrEMBL |
B0QZM2
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UniProt Splice Variant |
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Entrez Gene |
140499
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UniGene |
Mm.371673
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RefSeq |
NP_001034248
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MGI ID |
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MGI Symbol |
Ube2j2
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OMIM |
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CCDS |
CCDS19051
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HPRD |
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IMGT |
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EMBL |
AF296656
AK004626
AK010302
AK076265
AL627204
BC065779
U93242
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GenPept |
AAF21504
AAH65779
AAK52607
BAB23421
BAB26835
BAC36280
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