InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ryr2

Summary

InnateDB Protein

IDBP-627399.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ryr2

Protein Name

ryanodine receptor 2, cardiac

Synonyms

9330127I20Rik; RYR-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127991

InnateDB Gene

IDBG-129559 (Ryr2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005216	ion channel activity
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0003220	left ventricular cardiac muscle tissue morphogenesis
GO:0003300	cardiac muscle hypertrophy
GO:0006355	regulation of transcription, DNA-templated
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0010460	positive regulation of heart rate
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0030509	BMP signaling pathway
GO:0031000	response to caffeine
GO:0055085	transmembrane transport
GO:0060070	canonical Wnt signaling pathway
GO:0060401	cytosolic calcium ion transport
GO:0070588	calcium ion transmembrane transport
GO:0071313	cellular response to caffeine

Cellular Component

GO:0005790	smooth endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0030018	Z disc
GO:0033017	sarcoplasmic reticulum membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:99685

InterPro

IPR000699 RIH (RyR and IP3R Homology) domain
IPR001870 B30.2/SPRY domain
IPR002048 EF-hand domain
IPR003032 Ryanodine receptor Ryr
IPR003877 SPla/RYanodine receptor SPRY
IPR005821 Ion transport domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009460 Ryanodine Receptor TM 4-6
IPR013333 Ryanodine receptor
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016032 Signal transduction response regulator, C-terminal effector
IPR016093 MIR motif
IPR018355 SPla/RYanodine receptor subgroup

PFAM