InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ryr2

Summary

InnateDB Gene

IDBG-129559.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ryr2

Gene Name

ryanodine receptor 2, cardiac

Synonyms

9330127I20Rik; RYR-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021313

Encoded Proteins

IDBP-129563

ryanodine receptor 2, cardiac

IDBP-627399

ryanodine receptor 2, cardiac

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198626:
This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:11553103-12106945

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021750	ENSMUSP00000021750
ENSMUST00000170156	ENSMUSP00000127991

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005216	ion channel activity
GO:0005218	intracellular ligand-gated calcium channel activity
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015278	calcium-release channel activity
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0034236	protein kinase A catalytic subunit binding
GO:0034237	protein kinase A regulatory subunit binding
GO:0042802	identical protein binding
GO:0043621	protein self-association
GO:0043924	suramin binding
GO:0048763	calcium-induced calcium release activity

Biological Process

GO:0001666	response to hypoxia
GO:0002027	regulation of heart rate
GO:0003143	embryonic heart tube morphogenesis
GO:0003220	left ventricular cardiac muscle tissue morphogenesis
GO:0003300	cardiac muscle hypertrophy
GO:0005513	detection of calcium ion
GO:0006355	regulation of transcription, DNA-templated
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0010460	positive regulation of heart rate
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019722	calcium-mediated signaling
GO:0030509	BMP signaling pathway
GO:0031000	response to caffeine
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0051284	positive regulation of sequestering of calcium ion
GO:0051775	response to redox state
GO:0055085	transmembrane transport
GO:0055117	regulation of cardiac muscle contraction
GO:0060048	cardiac muscle contraction
GO:0060070	canonical Wnt signaling pathway
GO:0060401	cytosolic calcium ion transport
GO:0060402	calcium ion transport into cytosol
GO:0070588	calcium ion transmembrane transport
GO:0071313	cellular response to caffeine
GO:0072599	establishment of protein localization to endoplasmic reticulum
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086029	Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:0086094	positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction
GO:0097050	type B pancreatic cell apoptotic process
GO:1901896	positive regulation of calcium-transporting ATPase activity

Cellular Component

GO:0005790	smooth endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0030017	sarcomere
GO:0030018	Z disc
GO:0033017	sarcoplasmic reticulum membrane
GO:0034704	calcium channel complex
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome